Generic Artane

TRIHEXYPHENIDYL HCl
Tablets: 2 and 5 mg (Rx) Various, Artane (Lederle)
Capsules, sustained release: 5 mg (Rx) Artane Sequels (Lederle)
Elixir: 2 mg/5 ml (Rx)

Indications
Adjunctive therapy in all forms of Parkinsonism (post-encephalitic, arteriosclerotic and idiopathic) and in the control of drug-induced extrapyramidal disorders.

Administration and Dosage
Parkinsonism - Initially, administer 1 to 2 mg the first day; increase by 2 mg increments at intervals of 3 to 5 days, until a total of 6 to 10 mg is given daily. Many patients derive maximum benefit from a total daily dose of 6 to 10 mg; however, post-encephalitic patients may require a total daily dose of 12 to 15 mg. Trihexyphenidyl is tolerated best if divided into 3 doses and taken at mealtimes. High doses may be divided into 4 parts, administered at mealtimes and at bedtime.
Concomitant use with levodopa: Trihexyphenidyl 3 to 6 mg/day in divided doses is usually adequate.
Drug-induced extrapyramidal disorders - Start with a single 1 mg dose. Daily dosage usually ranges between 5 to 15 mg, although reactions have been controlled on as little as 1 mg/day.
Sustained release - Do not use for initial therapy. Once patients are stabilized on conventional dosage forms, they may he switched to sustained release capsules on a milligram per milligram of total daily dose basis. Administer as a single dose after breakfast or in 2 divided doses 12 hours apart.
PARKINSON & ALZHEIMER

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