Generic Voltarol (Diclofenac 100mg)
DICLOFENAC
Tablets: 50 mg (as potassium) (Rx) Various, Cataflam (Novartis)
Tablets, delayed-release: 25, 50, and 75 mg Various, Voltaren (Novartis)
(as sodium) (Rx)
Tablets, extended-release: 100 mg (as sodium) (Rx) Voltaren-XR (Novartis)
Indications
Rheumatoid arthritis and osteoarthritis: Relief of signs and symptoms; treatment of acute flares and exacerbation; long-term management.
Concomitant therapy -Concomitant therapy with other second-line drugs (e.g., gold salts) demonstrates additional therapeutic benefit. Whether they can be used with partially effective doses of corticosteroids for a "steroid-sparing" effect and result in greater improvement is not established.
Use with salicylates is not recommended; greater benefit is not achieved, and the potential for adverse reactions is increased. The use of aspirin with non-steroidal anti-inflammatory agents (NSAIDs) may cause a decrease in blood levels of the non-aspirin drug.
Administration and Dosage
Osteoarthritis - 100 to 150 mg/day in divided doses (50 mg twice/day or 3 times/ day [diclofenac sodium or potassium] or 75 mg twice/day [diclofenac sodium]). Dosages > 200 mg/day have not been studied.
Rheumatoid arthritis - 150 to 200 mg/day in divided doses (50 mg 3 or 4 times/day [diclofenac sodium or potassium] or 75 mg twice/day [diclofenac sodium]). Dosages > 225 mg/day of the delayed-release diclofenac sodium formulation and dosages > 200 mg/day of immediate-release diclofenac potassium formulation are not recommended.
Ankylosing spondylitis - 100 to 125 mg/day as 25 mg 4 times/day, with an extra 25 mg dose at bedtime, if necessary. Dosages > 125 mg/day have not been studied.
Analgesia and primary dysmenorrhea (diclofenac potassium only) - Recommended starting dose is 50 mg 3 times/day. In some patients, an initial dose of 100 mg followed by 50 mg doses will provide better relief. After the first day, when the maximum recommended dose may be 200 mg, the total daily dose should generally not exceed 150 mg.
ARTHRITIS
ENVIRONMENTAL FACTORS INFLUENCING ON ARTHRITIS DEVELOPMENT
The environmental factors if a patient's arthritis symptoms are intensified in autumn include the following:
1. Internal effects caused by absorption of arthritis-producing factors from inhaled airborne pollens released from local weeds and late-pollinating grasses. It is not widely known that highly reactive grass pollens can cause considerable allergic trouble during the ragweed season. On many occasions it has been noted that the local grass-pollen count has been higher than the weed-pollen count during weed-pollen season.
2. At this time of year the atmosphere can be loaded with the enormous quantities of reproductive spores and broken threads of many species of very potent molds. After inhalation of these airborne allergens, substances in these molds can also be absorbed internally from the moist surfaces of the nose and throat they come in contact with and ultimately reach the allergically sensitive cells in the joints and muscles that are involved in cases of mold-allergy arthritis.
3. The house is now closed to conserve heat; this causes an increase in the concentration of several types of allergenic substances in indoor air, such as house dust, dust mites, pet dander, and molds - in addition to the odors of cooking foods and the chemical fumes of a variety of maintenance materials employed in housekeeping, and the gassing out from synthetic furnishings, cosmetics, and volatile, odorous materials employed while engaging in hobbies.
4. When nonelectric heating systems are turned on, the combustion products of fuel oil, natural gas, kerosene, coal, or wood may pollute the indoor environment. In addition, the blower in a hot-air heating system distributes airborne offenders of many types throughout the house.
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HEALTHY BONES
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