Generic Uniphyl Tr

1. Denomination

Aerolate, Theo-24

2. Active Substance

Theophylline

3. Indications for Use.

Bronchial asthma
Symptomatic treatment of bronchospasm of various etiologies
Lung hypertension
Chained-Stokes respiration failure
Night apnea, migraine
Stroke

4. Action

Theophylline enlarges bronchi, blood vessels, mainly the vessels of brain, skin and kidneys. The drug decreases lung vessel resistance and tension in lesser circulation.
Theophylline takes spasmolytic effect to peripheral veins, increases renal blood flow; it takes a moderately manifested urinative effect.
Theophylline takes stimulating effect on respiration center; it enhances heart rate and heart force.

5. Posology and Administration

Posology and administration are to be set up individually. An average starting dose is 400 mg /daily. Upon condition of good tolerance a dose may be increased approximately by 25% from the starting one every 2-3 days up to attainment of the optimal therapeutic effect. Maximal daily doses which may be applied without a control of blood concentration are: children of 1-9 years of age — 24 mg/kg, 9-12 years of age — 20 mg/kg, 12-16 years of age — 18 mg/kg; patients of 16 years of age and older — 13 mg/kg or 900 mg/daily.

6. Counterindications

Age under three years, hypersensitivity to Theophylline, epilepsy, increased readiness for convulsions, gastric and duodenal ulcer.

7. Should Be Taken with Precautions, if…

With caution it should be used in severe stenocardia, in acute periods of myocardial infarction and heart failure. Likewise caution is needed in evidenced compromised liver and kidney function, during pregnancy and lactation. In severe diseases of cardio-vascular system, also in elderly patients a Theophylline dose should be decreased.

8. Interface with Other Medications

Do not try shots of self-administration (especially of combination of drugs) of medications without a doctor’s assistance.

9. Overdosing

Symptoms: strong emotional excitement, accompanied with a feeling of anxiety and fear, confusion of consciousness, convulsions, tachycardia, arrhythmia, low arterial tension, nausea, diarrhea, vomiting with bloody tap. Diabetes, pains in muscles, muscle weakness.

10. Side Effects

Irritation of mucus coating of the stomach, nausea, agitation, insomnia, tachycardia, arrhythmias, low arterial tension. Side effects will decrease when a Theophylline dose decreases.

11. Pregnancy and Lactation

Theophylline therapy during pregnancy is possible only in the cases when a supposed therapy effect exceeds a potential risk for the fetus, provided there is no alternative reliable therapy. During the treatment breast-feeding should be cancelled.

12. Driving

Before you start the activities which require alertness see how your body responds to Theophylline.

WHAT IS SLEEP APNOEA?
Sleep apnoea (Pickwickian syndrome) is characterized by recurrent episodes of disrupted breathing, for 10 seconds or more, at a frequency of over 30 times per night, causing hypoxia and increased levels of carbon dioxide in the blood. It mainly disturbs the quality of rapid-eye-movement (REM) sleep and there can be as many as 20 or 30 episodes per hour; there is a strong association with snoring. The condition affects up to 4% of adults and is more common in men than women by about 4 to 1, although postmenopausal women who are not on HRT have an increased prevalence.
Spouses will often describe episodes when breathing stops for periods of up to a minute, followed by a loud grunt and the resumption of a normal pattern; sufferers describe startled awakening and choking. Daytime symptoms include drowsiness and somnolence, fatigue, memory loss, headaches and mood swings.
Studies show that almost half of patients complaining of daytime somnolence suffer from sleep apnoea. Complications include pulmonary hypertension, right heart failure, hypertension, stroke and cardiac arrhythmias, especially bradycardia, atrial flutter and ventricular tachycardia. The main cause of mortality is accidental death caused by falling asleep in inappropriate situations; there is a seven-fold increase in car accidents among sufferers of sleep apnoea. It is thought that there might be an increased risk of myocardial infarction but the evidence for this is inconclusive.
*3/312/5*
ANTI-ALLERGIC/ASTHMA

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