Generic Triderm

TRIAMCINOLONE
Inhaler: 55 mcg triamcinolone acetonide/actuation (Rx) Nasacort (Aventis)
Spray: 55 mcg triamcinolone acetonide/actuation (Rx) Nasacort AQ (Aventis)
50 mcg trimacinolone acetonide/spray (Rx) Tri-Nasal (Muro)

Indications
Treatment of seasonal and perennial allergic rhinitis symptoms in adults and children > 6 years of age (Nasacort and Nasacort AQ) or > 12 years of age (Tri-Nasal).

Administration and Dosage
Adults and children > 12 years of age -
Nasacort: The recommended starting dose is 220 mcg/day given as 2 sprays (55 mcg/spray) in each nostril once a day. The dose may be increased to 440 mcg/ day (55 mcg/spray) either as once-a-day dosage or divided up to 4 times/day (i.e., twice a day [2 sprays/nostril] or 4 times/day [1 spray/nostril]). After desired effect is obtained, some patients («= 50%) may be maintained on as little as 1 spray in each nostril once a day. The degree of relief does not seem to be significantly different when comparing 2 or 4 times/day dosing with once-a-day dosing.
A dose response between 110 and 440 mcg/day is not clearly discernible. In general, the highest dose tends to provide relief sooner. This suggests an alternative approach to starting therapy: Start treatment with 440 mcg (4 sprays/nostril/ day), and then, depending on response, decrease the dose by 1 spray/day every 4 to 7 days.
Nasacort AQ: The recommended starting and maximum dose is 220 mcg/day as 2 sprays in each nostril once daily. When the maximum benefit has been achieved and symptoms have been controlled in patients initially controlled at 220 mcg/ day, decreasing the dose to 110 mcg/day (1 spray in each nostril/day) has been demonstrated to be effective in allergic rhinitis symptoms.
Tri-Nasal: The recommended starting dose for most patients is 200 mcg (2 sprays/nostril) once daily. The dose may be increased to a maximum of 400 mcg (4 sprays/nostril) once daily. An alternative 400 mcg/day dosing regimen may be given as 200 mcg twice daily (two 50 mcg sprays in each nostril twice daily). Do not exceed the maximum daily dose of 400 mcg. After symptoms have been brought under control, the patient should be titrated to the minimum effective dose.
Children 6 to 12 years of age -
Nasacort: The recommended starting dose is 220 mcg/day given as 2 sprays (55 mcg/spray) in each nostril once a day. Once the maximal effect has been achieved, titrate the patient to the minimum effective dose.
Nasacort AQ: The recommended starting dose is 110 mcg/day given as 1 spray in each nostril once daily. The maximum recommended dose is 220 mcg/day as 2 sprays/nostril once daily. Once symptoms are controlled, pediatric patients may be maintained on 110 mcg/day (1 spray in each nostril per day).
Nasacort and Nasacort AQ are not recommended for children ANTI-ALLERGIC/ASTHMA

PHOW ALLERGIES HAPPEN
If you have the inherited ability to form IgE to some allergic substance and you are exposed sufficiently to that substance, you will then form IgE antibodies against that substance. Once these IgE antibodies are formed, they attach themselves to certain cells in the lining of your nose - mast cells and basophil cells - and await re-exposure to the substance responsible for their generation. When re-exposure occurs, the IgE antibodies bind with the substance. This binding initiates a sequence of events that culminate in the release of chemicals from the interior of the cell and from the cell wall into the nasal lining. These chemicals, called chemical mediators, cause small blood vessels to dilate, fill with blood, and leak fluid into the nasal tissue. Swelling of the lining of the nose results. Other mediators stimulate nasal nerves and mucus-producing cells. Still other mediators attract into the nasal tissue cells of inflammation, and these then contribute their own set of mediators to produce an ongoing inflammatory reaction. All of this creates what we call symptoms: nasal congestion, runny nose, drainage, sneezing, itching, and a twitchy nose.
*7/322/5*
ANTI-ALLERGIC/ASTHMA

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