Generic Starlix (Nateglinide 60/120mg)
- Denomination
Starlix
- Active Substance
Nateglinide
- Indications for Use.
Nateglinide is indicated as a monotherapy aimed for decreasing of the glucose level in blood in type 2 sugar diabetes patients (insulin independent sugar diabetes), for whom the control of the glycemia level diet and physical exercises are not enough and who have not got any long-term treatment with other hypoglycemic agents.
- Action
Nateglinide restores an early insulin secretion which will result in deflation of glucose content in blood.
- Posology and Administration
The drug is to be taken orally, directly before meal (the time between the drug administration and eating should not exceed 30 minutes). During monotherapy a recommended dose is 120 mg 3 times a day (before breakfast, lunch and dinner). If the desired effect has not worked out a single-shot dose will be decreased up to 180 mg. Dosage regime correction is to be carried out regularly on the basis of regularly determined findings of the blood picture.
Combined treatment should be carried out on doctor’s order and under doctor’s control.
While compromised kidneys function there is no need to correct dosage regime.
- Counterindications
– type 1 sugar diabetes (insulin dependent);
– diabetic ketoacidosis;
– evidenced compromised liver function (due to the absence of data of clinic studies for this population of patients);
– pregnancy;
– lactation (breastfeeding);
– childhood (due to the absence of data of clinic studies for this age group of patients);
– hypersensitivity to the drug’s components.
- Should Be Taken with Precautions, if…
While using Starlix for type 2 diabetes patients (insulin dependent) precautionary measures concerning the emergence of hypoglycemia should be observed. Drop of glucose concentration in blood may be provoked by alcohol intake and intense physical load.
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Interface with Other Medications
Administration of other medications in the period of Nateglinide therapy only the attending doctor may do in clinic.
- Overdosing
Cases of overdosing of Nateglinide have not been described yet.
Symptoms: reasoning from the knowledge of the mechanism of the drug’s action, one may suppose that the main result of overdosage will be hypoglycemia with clinical presentations of varying severity.
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Side Effects
Symptoms: elevated perspiration, tremor, dizziness, hyperorexia, heart beat, nausea, weakness, lack of energy; transient imperceptible rise of potency of “liver” transaminases in blood, allergic reactions – rash, itching, hives.
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Pregnancy and Lactation
Nowadays there is no experience of the use of Nateglinide in pregnancy; therefore there is no possibility to assess its safety. It is not well to use this drug during pregnancy. Nateglinide should not be administered to breastfeeding mothers because of the risk of the development of hypoglycemia in the baby, in case if a certain quantity of the drug, even if it is but small, excretes with breast milk.
- Driving
Patients who work with mechanisms and drive vehicles should take special precautionary measures.
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