Generic Oxytrol

1. Denomination

Ditropan

2. Active Substance

Oxybutynin Chloride

3. Indications for Use.

Incontinence of urine due to neurogenic instability of the bladder’s function (detrusor hyperreflexia, for instance, when there is multiple sclerosis or spina bifida) or that of idiopathic character; night enuresis in children over 5 years of age (as a monotherapy or in combination with other medications).

4. Action

Oxyburtynin Chloride eliminates spasms and lowers the tonus of smooth muscles: of intestinal tract, bile and urine passages, womb, especially it is good in relaxing smooth muscles of bladder. In neurogenic bladder patients Oxyburtunin Chloride increases the capacity of the bladder, relaxes and reduces the frequency of muscle contraction of the bladder, restrains urges and reduces the number of urinations (unintentional and voluntary ones).

5. Posology and Administration

The drug is administered individually in compliance with the diagnosis and with the patient’s state.
Oxyburtynin Chloride should be taken orally. Adults should take 5 mg each 2-3 (less common 4) times/a day. In elderly patients in the beginning of the treatment there is applied a dose of 2.5-3 mg each twice/daily, further on, if needed, the dose may be increased step by step up to 5 mg each twice /daily.
In children over 5 years of age – a starting dose is 2.5-3 mg each twice/daily, if needed the dose may be increased step by step up to 5 mg each 2-3 times/daily. When there is night enuresis the last dose should be taken immediately before bedtime.

6. Counterindications

Disorder of urine outflow from the bladder, bowel obstruction; atony of bowels; severe ulcerative colitis; distention of segmented intestine, myasthenia; glaucoma; lactation (breastfeeding); childhood under 5 years of age; hypersensity to Oxybutynin.

7. Should Be Taken with Precautions, if…

With care it will be applied in elderly patients, in NCD patients (neurocirculatory asthenia), compromised liver or kidneys function, thyrotoxicosis, arrhythmia, ischemic heart disease, chronic heart failure, high arterial tension, initial manifestations of benign (tumor or several small tumors), prostate gland in men, NUC (nonspecific ulcer colitis), in patients after surgery in the area of intestinal tract, likewise in patients with the hernia of esophageal opening, accompanied with inflammation.

8. Interface with Other Medications

The use of other drugs in the period of treatment without a doctor’s order is not recommended, as such combination of substances may result in unpredictable consequences for the health.

9. Overdosing

Symptoms: agitation of CNS (unrest, tremor, irritancy, convulsions, delirium, hallucinations), face reddening, fever, nausea, vomit, tachycardia, hypo- or hypertension, respiratory distress, paralysis, coma.

10. Side Effects

Constipations, dry mouth, decrease of perspiration, drowsiness, blurred vision, decrease of sexual activity, deglutitive problem, headache, nausea and vomit, troubled sleep, fatigability and weakness.
The less common side effect of which you should tell your doctor immediately is: stranguria.

11. Pregnancy and Lactation

In pregnancy Oxybutynin should not be administered. In the period of treatment breastfeeding should be withdrawn, as the drug excretes into breast milk and there is a high probability of emergence of side effects in the infant.

12. Driving

To get behind a wheel you can only after you have made sure that Oxybutynin does not give side effects to your body and you in reality are able to drive a car.

 CRUCIAL FACTS ABOUT CHOLESTEROL
Cholesterol alert! It seems that no matter whom you talk to these days, no matter what you read or watch on television, the message is the same: Americans are very concerned about cholesterol.
And with good reason. Not long ago, if you had a cholesterol level of between 250 and 300 milligrams per deciliter (100 milliliters) of blood, your doctor would probably have dismissed you with a clean bill of health. But today this scenario is changing sharply. A 1986 landmark study based on more than 350,000 subjects by Dr. Jeremiah Stamler, an epidemiologist from Northwestern University, confirmed that nearly half of all fatal heart attacks among the subjects in the study resulted from cholesterol readings above 180 rag/ dl. For those subjects whose cholesterol levels were significantly elevated (245 mg/dl or higher), the risk of fatal heart attack was in fact at least as great as the risk from smoking and high blood pressure combined.
As a result of this and other new research, the National Cholesterol Education Program (NCEP) has stated that at least one in four American adults who were previously considered fit and free of risk will find out that they have a serious problem with cholesterol - and that they need to adjust their eating habits accordingly. In fact, most other people who were previously considered fit and free of risk probably aren't, either: Among the people of Framingham, Massachusetts, for example, whose cardiovascular health has been the subject of an ongoing study for more than forty years, only those with a cholesterol level below 150 mg/dl have been found to be free of risk for premature death due to clogged arteries.
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CARDIO & BLOOD

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