Generic Norethindrone

NORETHINDRONE
(Micronor, Norlutin, Nor-Q.D.)
Norethindrone is a synthetic progestin that is used as an oral contraceptive (when formulated with an estrogenic compound) and in treatment of menstrual disorders. The dose used to treat endometriosis (up to 15 mg/d) is much greater than that currently used in oral contraceptives (0.4-2.5 mg/d).

Teratogenic Risk
Magnitude of teratogenic risk to child born after exposure during gestation:
Non-genital congenital anomalies: None.
Virilization of female fetus with large doses (used to treat endometriosis): Small.
Virilization of female fetus with small doses (used in oral contraceptives): None.
Quality and quantity of data on which risk estimate is based:
Non-genital congenital anomalies: Fair.
Virilization of female fetus with large doses (used to treat endometriosis): Fair.
Virilization of female fetus with small doses (used in oral contraceptives): Fair.

Maternal use of large doses of norethindrone during pregnancy has associated with the occurrence of masculinization of the external Italia in female infants. The genital anomalies observed include various degrees of clitoral hypertrophy with or without labioscrotal fusion. Internal genitalia and pubertal development are not affected. Labioscrotal fusion is associated with exposure between the seventh and thirteenth week of gestation, but clitoral hypertrophy can develop with exposure at this time or later in pregnancy. The frequency of genital virilization among daughters of women who took norethindrone during pregnancy in doses similar to or greater than those used to treat endometriosis was 13% and 19% in clinical series of 39 and 82 female infants, respectively.
The overall frequency of congenital anomalies was not significantly greater than expected among the children of 132 women who took norethindrone during the first four lunar months of pregnancy or of 148 women who took this drag anytime in pregnancy in a large epidemiological study. In another study, maternal use of norethindrone during pregnancy was not significantly increased among 171 children with various congenital anomalies. Similarly, the frequency of hormonal pregnancy tests using norethindrone and ethinyl estradiol (an estrogenic agent) during the second month of pregnancy was not increased among the mothers of 194 infants with major malformations or 551 infants with minor congenital anomalies.
Masculinization of the genitalia of female offspring can be induced in several species of experimental animals by treatment of the mother with norethindrone in high doses during pregnancy.
Studies in nonhuman primates, mice, and rabbits suggest that treatment of pregnant women with norethindrone in usual therapeutic or contraceptive doses is unlikely to increase the children's risk of non-genital congenital anomalies greatly.

Risk Related to Breast-feeding
Norethindrone is excreted in breast milk. The amount of norethindrone that the nursing infant would be expected to ingest is Norethindrone concentrations ranging from 0.07-0.42 ng/mL were measured in the serum of 15 breast-fed infants whose mothers took an oral contraceptive containing norethindrone. These levels of norethindrone were between 4-25% of those found in the maternal serum. In another study, no norethindrone was found in the serum of breast-fed infants whose mothers had been given an intramuscular injection of norethindrone.
Maternal use of norethindrone as a contraceptive during lactation had no adverse effects on growth or development of infants followed up to one year of age.
WOMEN’S HEALTH

BONE LOSS IN WOMEN
As humans age, a loss of bone occurs. According to a new study, "roughly half of all women aged 50 or older have either low bone mass or osteoporosis and don't know it." The following factors can contribute to low bone mass and osteoporosis:
• Women start their lives with less bone mass than men. Therefore, once bone loss occurs, women lose a greater percentage of that bone than men.
• Excessive dieting in adolescence. Dieting in young people can cause bones to develop improperly. Later in life, the fact that the bone was not properly formed contributes to a more rapid diminishment of bone mass.
• Age-related loss of bone mass. During the first five to seven years after menopause, women lose as much as 20 percent of their bone mass. This is in addition to the loss that occurred from the age of twenty until menopause if you had not been performing strength and resistance exercise.
• Calcium deficiency. Calcium is an essential mineral for reducing the risk of bone mass loss, osteoporosis, and fractures. From the ages of nineteen through fifty, adults need 1,000 milligrams of calcium a day, according to the National Academy of Science's Institute of Medicine. After age fifty-one, you need 1,200 milligrams. Postmenopausal women not taking estrogen need 1,500 milligrams, according to doctors at Harvard Medical School, as do all adults over age sixty-five. Pregnant or lactating women also have special needs (ranging from 1,000 to 1,300 milligrams, depending on age). Check with your doctor to get the latest calcium guidelines.
According to the April 2001 issue of Medicine & Science in Sports & Exercise, "bone mineral density is affected by genetics, exercise, hormonal status and nutrition. Although genetics appears to have the greatest impact, exercise can modify the peak bone mass a person acquires or maintains."
Bone expert C. Conrad Johnston of the Indiana University School of Medicine describes osteoporosis simply by stating that "people think bone is structurally like steel, but it's actually an active organ. Osteoclasts are cells that keep digging holes in the bone, while osteoblasts keep filling them back in." Therefore, you can control the rate at which you lose and regain bone through strength and resistance exercise and proper nutrition.
Numerous variables can halt or slow the loss of bone and perform the function of the osteoblasts. One of these is consuming the following foods:

Foods That Slow Bone Loss
Nutrient Milligrams Foods
Calcium 1,000-1,200 Dark green leafy vegetables, broccoli,
canned salmon and sardines, yogurt and cottage cheese
Vitamin С 200 Citrus fruits, strawberries, kiwi,
papaya, mango, broccoli, tomatoes, potatoes, cantaloupe
Vitamin D 700-1,000 Vitamin D-fortified milk
Vitamin К 90-120 Brussels sprouts, broccoli, dark green leafy vegetables
Yes, women can win "the battle of the bone." All that's required is knowledge and attention.
*1/280/5*
WOMEN’S HEALTH

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