Generic Naprelan

1. Denomination

Naprosyn

2. Active Substance

Naproxen

3. Indications for Use.

· rheumatoid arthritis;
· osteoarthritis;
· ankylosing spondylitis;
· acute fit of gout;
· pains in the spine;
· neuralgias;
· myalgias;
· traumatic inflammation of soft tissues and locomotor apparatus;
· primary dysmenorrhea.

4. Action

Naproxen takes evidenced anti-inflammatory, nonnarcotic, antipyretic action.

5. Posology and Administration

Naproxen should be taken orally. Tablets should be taken in whole, rinsing them with liquid; they are possible to be taken during meal. In acute stage of the disease they may be taken 0.5-0.75 g each 2 times a day. The maximal daily dose is 1.75 g. For maintenance therapy an average daily dose should be 500 mg in 2 intakes (in the morning and before bedtimeу). When there is acute fit of gout the first dose should be 825 mg; then 275 mg every 8 hours. In event of menstrual colic the first dose should be 500 mg, and then there should be 275 mg each every 6-8 hours during 3-4 days. In event of migraine a dose should be 500 mg. Rectal suppositories usually are administered before bedtime (one suppository of 0.5 g each). If it is a need to use Naproxen in high doses it is possible to combine administrations in suppositories and tablet. In children of the age from 1 year to 5 years the drug should be administered in a daily dose of 2.5-5 mg/kg in 1-3 intakes; a course of the treatment should not exceed 14 days. In event of juvenile arthritis in children over 5 years of age a daily dose should be 10 mg/kg. Suspension is a preferable drug formulation for children.

6. Counterindications

  ulcer disease of stomach and duodenal in an aggravation phase;
  bronchial spasm fits due to NSAID administration (in anamnesis);
  hemorrhagic diathesis;
  pregnancy;
  childhood (under 16 year of age);
  hypersensitivity to Naproxen

7. Should Be Taken with Precautions, if…

Care should be taken in administering of Naproxen to the patients with compromised functions of liver and/or kidneys, gastrointestinal diseases, arterial hypertension, heart failure, immediately after a serious surgery interventions.
 Caution is needed in administration of Naproxen to elderly people, especially in compromised kidneys function.
There should be taken in consideration that Naproxen increases bleeding time.

8. Interface with Other Medications

Attention!
Before the application of Naproxen a doctor’s advice is needed. Naproxen in simultaneous use with other drugs may provoke either effect reduction or effect enhancement.

9. Overdosing

Symptoms: drowsiness, heartburn, dyspepsia, nausea, vomit.

10. Side Effects

On the part of gastrointestinal tract: nausea, vomit, constipation, discomfort sensation in the pit of the stomach, seldom – stomach bleeding.
On the part of central nervous system and sense organs: headache, drowsiness, seldom – hearing disorders, visual distortion.
Allergic and immunopathological reactions: skin rash, hives, Quincke’s disease; seldom – hemolytic anemia, thrombocytopenia, agranulocytosis.

11. Pregnancy and Lactation

Should be taken with caution in pregnancy (especially in the I-st and III-d trimesters) and lactation period.
Naproxen penetrates through placental barrier and excretes with breast milk in small quantities.

12. Driving

In event of drowsiness and “haziness” of vision, weakness, vehicles driving and other alertness-requiring actions should be avoided.

 PHYSICAL ACTIVITIES FOR PATIENTS WITH RHEUMATOID ARTHRITIS
Rheumatoid arthritis is a chronic disease of the joints, usually symmetric polyarthritis, marked by inflammatory changes in the synovial membranes and articular structures and by atrophy and rarefaction of the bones. It is generally more common in females than males. There is no evidence that exercise prevents rheumatoid arthritis.
Previously, the cornerstone of treatment of active rheumatoid arthritis was bed rest, and patients were restrained from active physical exercise based upon the presumption of its detrimental effect on disease activity and joint erosiveness. However, inactivity as a treatment for rheumatoid arthritis is now contraindicated, based on several studies that uniformly show that physical therapy and moderate-intensity exercise not only reduce hand pain, stiffness, and joint tenderness, but also improve activity-of-daily-living scores.
The intensity of the exercise should be well matched with the disease activity to best meet each person's needs, taking into account the severity of the arthritis, the patient's other medical problems, and the patient's individual lifestyle and preferences. Physical inactivity results in muscle atrophy and bone loss, even in healthy individuals. Exercise in patients with rheumatoid arthritis appears to minimize loss in muscle strength, but not the loss in bone density. The mechanisms by which physical activity reduces pain, stiffness, and joint tenderness in patients with rheumatoid arthritis are not well understood.
*2/282/5*
HEALTHY BONES

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