Generic Meticorten

PREDNISONE/PREDNISOLONE
(Deltasone, Meticorten, Orasone)
Prednisone and prednisolone are synthetic glucocorticoids. Prednisone is biologically inert; it is converted to prednisolone, a biologically active compound, in the liver. Prednisone and prednisolone are used to treat a variety of allergic and inflammatory conditions. Prednisone is given orally but prednisolone may be given either orally or parenterally. The usual systemic dose of either agent is 5-60 mg/d, but doses up to 250 mg/d are sometimes used. Systemic absorption of prednisolone can occur from ophthalmic preparations, but the amount administered is usually small.

Teratogenic Risk
Magnitude of teratogenic risk to child born after exposure during gestation: Unlikely.
Quality and quantity of data on which risk estimate is based: Poor to fair.
Therapeutic doses of prednisone and prednisolone are unlikely to pose a substantial teratogenic risk, but the data are insufficient to state that there is no risk.

The frequency of malformations was not increased among the children of 43 women who had been treated with prednisone during the first four lunar months of pregnancy in one epidemiological study. Malformations do not appear unusually frequent among the infants of women treated with prednisone during pregnancy in uncontrolled series of 20-40 live-births.
Congenital immunodeficiency and lymphopenia have been reported in two infants born to women who had been treated with prednisone and azathioprine during pregnancy. It is uncertain whether or not the maternal immunosuppressive therapy played a role in development of this disease in the infants.
A high frequency of perinatal death has been observed in some series of women treated throughout gestation with prednisone or prednisolone, but the perinatal death cannot be attributed to maternal steroid therapy because these women had serious illnesses requiring treatment, often with several drugs. Premature delivery and fetal growth retardation are also unusually frequent in some series of women treated during pregnancy with prednisone or prednisolone, but the same confounding factors affect interpretation of the studies.
Fetal growth retardation occurs with increased frequency among the offspring of mice and rats treated in pregnancy with prednisone or prednisolone in doses within or above the human therapeutic range. Dose-dependent constriction of the ductus arteriosus was observed among the offspring of pregnant rats injected with prednisolone near term in doses 10-1000 times those used in humans.
Prednisolone, like other corticosteroids, causes an increased frequency of cleft palate in the offspring of pregnant mice treated with 1-40 times the human therapeutic dose. Increased frequencies of cleft palate are also observed among the offspring of pregnant rabbits and hamsters treated with prednisolone in doses respectively

Risk Related to Breast-feeding
Prednisone and its active metabolite, prednisolone, are excreted in breast milk in low concentrations. The amount of prednisone and prednisolone that the nursing infant would be expected to ingest is ANTI-ALLERGIC/ASTHMA

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