Generic Grifulvin

1. Denomination

Grisactin

2. Active Substance

Griseofulvin Fulvicin

3. Indications for Use.

Griseofulvin is one of the main remedies for the treatment of dermatomycoses (skin fungous diseases). It is administered for the treatment of patients suffering from favus (skin fungous disease, mainly of the scalp), trichophytia and microsporia (parasite fungous diseases) of the scalp and smooth skin, epidermophytia (skin diseases provoked by filamentous parasite fungi), smooth skin provoked by Trichophyton (causative fungous of ringworm), likewise patients suffering from the nails damages provoked by pathogenic fungi (fungi-parasites, which provoke such human’s diseases as Trichophyton, red Epidermophyton).

4. Action

Griseofulvin takes anti-fungous action, retarding the growth and procreation of disease-producing fungi. As a consequence, it relieves patients from the symptoms (itching, burn, pains etc.)

5. Posology and Administration

The mode of administration and doses. The tablets are to be taken orally during meal (with one tea spoon of vegetable fat). Suspension (suspended matter of solid particles in fluid) is indicated for children under 3 years of age. The ointment is used independently to cure limited skin lesions and it is combined with an oral intake of the drug.
In microsporia for adults 8 tablets a day is to be administrated, whereas for children it is administrated on the basis of 21-22 mg/kg a day. The drug is to be taken daily up to the first negative fungous analysis, then in the same dosage rate during 2 weeks every other day and 2 weeks twice a week.
In superficial and infiltrative and suppurant form (a form of disease provoking induration of the skin and appearance of abscesses in the skin) forms of Trichophytia and favus adults are administered the same dose, children are to be administered 18 mg/kg (on the same scheme).
In the process of the treatment in Mycoses patients (fungous diseases) of the scalp it is necessary to shave off the hair every week and wash the head with water and soap twice a week. It is recommended to rub into the head’s skin anti-fungal ointments and to smear the lesion focuses with 2-3% spirit of iodine.
In onychomycoses, trichophytias and favus of the scalp a daily dose of Griseofulvin for adults with the body mass less than 50 kg is 5 tablets (625 mg), and in a bigger body mass any 10 kg of additional weight 1 tablet of the drug should be added, but not more than 1 g (8 tablets) daily. Children and adolescents suffering from onychomychoses should be administered 16 mg/kg daily. In onychomycoses the drug should be taken during the first month daily, whereas during the second month every other day, further on – twice a week.
The total treatment should not be less than 8 months.
In onychomycoses it is recommended to combine Griseofulvin therapy with removal of nails with keratolyc remedies (in this case provoking softening and tearing away of the nails) and apply anti-fungal drugs. The ointment is to be smeared with a thin layer in a daily dose of not more than 30 g. on the focuses of disease. The treatment is to be continued not less than 2 weeks after clinical symptoms have disappeared and after three negative results in a microscopic study.

6. Counterindications

Porphyries, systemic lupus erythematosus, lupus syndrome, system blood diseases, organic diseases of liver and kidneys, malignant neoformations, pregnancy.

7. Should Be Taken with Precautions, if…

 Due to a negative influence on reproductive function (both in men and in women) during Griseofulvin therapy one should use efficient non-hormonal contraception methods. Safety of the drug use during lactation is not determined. Patients who are taking Griseofulvin should be advised that alcohol may enhance its performance during Griseofulvin therapy.
The drug should not be administered outpatiently (extra-mural care) to drivers of vehicles, to airmen and to people engaged in elevated jobs.
In diathesis and diabetes suspension should not be administered (due to the sugar containing in it).

8. Interface with Other Medications

Concerning simultaneous administration of medications - take opinion of you doctor to start with.

9. Overdosing

There is no information of overdosing cases. In any case do not use more that it has been ordered by your doctor and in cases of acute manifestation of side effects see your doctor right away.

10. Side Effects

While using Griseofulvin dyspeptic events are possible (digestive upsets), headache, nausea, dizziness, disorientation events (loss of orientation), hives, leucopenia (low level of leucocytes in blood), less frequent leucocytosis (high number of leucocytes in blood). In theses cases it is recommended to make a break in the treatment for 3-4 days; in easy cases it is enough to reduce a daily dose during 4-5 days.

11. Pregnancy and Lactation

The drug is counterindicated in pregnancy. It is not recommended to use while breastfeeding.

12. Driving

The patients of Griseofulvin therapy should refrain from the hazardous activities, which require alertness and quick psychic reaction and motor response.

DISEASES OF CONNECTIVE TISSUE: SCLERODERMA AND DERMATOMYOSITIS
Scleroderma
Scleroderma is a disease that affects the connective tissue of the body and particularly that in the skin where there is hardening. Chiefly women between thirty and fifty years old are affected. The swelling in the skin may be followed by calcification. This disease comes on slowly and insidiously, but as it progresses changes occur in the skin of the face, neck, and arms. The skin looks waxy and tight and loses its color and hair. When the face is involved there may be difficulty in moving the jaw. Fortunately this is not a common disease; certainly it is not as serious as polyarteritis nodosa or diffuse lupus erythematosus, which are similar. In the older forms of treatment emphasis was placed on the use of thyroid and vitamins. Great care was given to prevent secondary infections. More recently attention is being focused on the use of ACTH and Cortisone.

Dermatomyositis
This is a common and often fatal disorder involving the skin and the muscles. The exact cause is still unknown. It affects people of all races and colors, both men and women, and in general those between the ages of ten and fifty years.
Characteristic of this condition is the involvement of the muscles. As they deteriorate the organs concerned show effects, as in the eyes, throat, diaphragm, or muscles between the ribs. The symptoms then are difficulties of vision, swallowing, breathing, speech, etc. Naturally such people lose weight and get weak. Unfortunately this condition is progressive and few who have it live long. Until recently little was known about treatment, and vitamins, hormones and physical therapy were tried. Salicylates were thought to be beneficial. Now we know that the salicylates can to a small extent stimulate the condition.
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SKIN CARE

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