Generic Eskalith

1. Denomination

Lithobid

2. Active Substance

Lithium Carbonate

3. Indications for Use.

Manic and hypomanic states of various genesis, affective psychosis (manic-depressive psychosis, schizoactive one), alcoholism (affective disorders); migraine, Meniere’s syndrome, sexual disturbances, drug dependence (some forms).

4. Action

The drug normalizes mental state, not provoking systemic retardation; likewise it takes anti-depressive, sedative and anti-manic effect and benefits in migraine.

5. Posology and Administration

The drug is to be taken orally (in 3-4 intakes, the last time before sleep), after meal, the starting dose is 0.6-0.9 g/daily with consequent increase up to 1.2 g/daily, then the dose is to be increased on a daily basis up to 0.3 g to attend a daily dose of 1.5-2.1 g; the maximal daily dose is 2.4 g., in the period of adjustment of therapy the concentration Li+ in plasma should be not less than 0.6 and not higher than 1.2-1.6 mmol/l. In the doses higher than 2 g/daily - time duration of the treatment should be 1-2 weeks. After manic symptoms and signs have disappeared a daily dose is to be gradually decreased to a prevention one (0.6-1.2 g). If after the decrease of the dose manic signs appear anew, the dose is to be increased. In acute manic state the therapeutic concentration of Li+ in blood should be 0.8-1.2 mmol/l, in supporting treatment it should be 0.4-0.8 mmol/l; if concentration Li+ exceeds 1.2 mmol/l, a daily dose should be reduced. A positive result of a preventive monotherapy is evident in case a stable concentration in blood of adults within the limit of 0.4-0.8 mmol/l is maintained not less than 6 months, whereas for children in a dose which allows to maintain therapeutic concentrations within a limit of 0.5-1 mmol/l.

6. Counterindications

Hypersensitivity, severe surgery interventions, kidney and/or liver diseases, severe cardio-vascular diseases, pregnancy, breastfeeding, the drug should not be used in children less than 12 years of age.

7. Should Be Taken with Precautions, if…

Cardiovascular diseases (including AV blockade, intraventricular block), diseases of central nervous system (epilepsy, Parkinsonism), diabetes, hormonal disturbance, disturbance of the function of endocrine system, infection, psoriasis, kidney failure, stanguria, disturbance water-electrolytic metabolism (salt-free diet, water retention, vomiting, diarrhea).
In the period of treatment alcohol consumption is prohibited.

8. Interface with Other Medications

On the questions of concurrent use of other medications during Lithium Carbonate therapy see your attending doctor.

9. Overdosing

Speech disturbance, rhythmic strain and muscle activity, tonic and epileptic convulsions, evolvement of very small quantity of urine, loss of consciousness, terminal state, coma.

10. Side Effects

Diarrhea, nausea, vomiting, dry mouth, polyuria, dysfunction of kidneys, disorders of cardiac rhythm, retardation of blood formation and activity of thyroid gland, weak trembling of hands, drowsiness, loss of head’s hair, pimples.
During Lithium Carbonate therapy temporary increase of the body mass and bronchocele formation are possible.

11. Pregnancy and Lactation

It is not recommended during pregnancy; during the therapy breastfeeding should be stopped.

12. Driving

In the period of treatment caution should be taken in vehicle driving and in involving of other potentially hazardous activities, requiring alertness and responsiveness.

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