Generic DiamoxAcetazolamide 250mgCardiovascular |
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Generic Diamox (Acetazolamide 250mg)
ACETAZOLAMIDE (Ak-Zol, Diamox) Acetazolamide is a carbonic anhydrase inhibitor used as a diuretic and in the treatment of glaucoma and certain kinds of epilepsy. Acetazolamide is also taken to prevent acute mountain sickness. The usual oral dose is 250-1000 mg/d. Oral doses up to 1500 mg/d or intravenous doses of 500-1500 mg/d are sometimes used to treat acute glaucoma. Teratogenic Risk Magnitude of teratogenic risk to child born after exposure during gestation: Unlikely. Quality and quantity of data on which risk estimate is based: Poor to fair. Therapeutic doses of acetazolamide are unlikely to pose a substantial teratogenic risk, but the data are insufficient to state that there is no risk. Congenital anomalies were no more frequent than expected among the children of 1024 women treated with acetazolamide during pregnancy in one large epidemiological study, but only 12 of these mothers were treated during the first four lunar months of gestation. An increased frequency of malformations was observed among 28 children of women treated with acetazolamide during the first trimester of pregnancy in another study, but the data presentation does not permit evaluation of the clinical significance of this association. It may have been due to factors other than the maternal acetazolamide therapy. Acetazolamide produces an unusual and specific limb malformation when administered to rats, mice, or hamsters early in pregnancy in doses many times those used clinically. These doses are often toxic to the mothers. Craniofacial and central nervous system malformations have also been reported, although less consistently, among the offspring of pregnant mice treated with acetazolamide in doses many times those used clinically. Fetal growth retardation, death, and axial skeletal malformations were observed with increased frequency among the offspring of pregnant rabbits treated with a few times the maximum human dose of acetazolamide. The relevance, if any, of these observations to the therapeutic use of acetazolamide in human pregnancy is unknown. Risk Related to Breast-feeding Acetazolamide is excreted into breast milk. The amount of acetazolamide that the nursing infant would be expected to ingest is approximately 5% of the lowest oral pediatric dose, based on data from a single patient. Serum concentrations measured in the infant between 20-60 % of the lowest adult therapeutic serum level. CARDIO & BLOOD
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