Generic Deltasone (Prednisolone 5/10/20/40mg)
- Denomination
Prednisolone
- Active Substance
Prednisolone
- Indications for Use.
Prednisolone is indicated for oral and intramuscular administration. Rheumatism, rheumatoid arthritis, multiple myositis, periarteritis nodosa; systemic sclerosis; Bekhterev’s disease. Bronchial asthma, status asthmaticus. Acute and chronic allergic diseases. Addison’s disease, acute failure of adrenal cortex, adrenogenital syndrome. Hepatitis, hepatic coma, hypoglycemic states, lipoid nephrosis. Agranulocytosis, various forms of leukaemia, malignant granulomatosis, thrombocytopenic purpura, hemolytic anemia. Hysterical chorea. Bubble fever, eczema, itch, exfoliative dermatitis, psoriasis, prurigo, seborrheic dermatitis, lupus erythematosus, erithroderma, alopecia.
For ophthalmology: allergic, chronic and uncharacteristic conjunctivitis and blepharitis; inflammation of cornea when mucous coat is intact; acute and chronic inflammation of anterior segment of vascular tunic, of sclera and episclera; sympathetic inflammation of eyebulb; after traumas and surgery in long-lasting irritation of eyebulbs.
For intra-articular introduction: chronic polyarthritis, post-traumatic arthritis, osteoarthritis of big joints, rheumatic affect of sporadic joints, arthroses.
For introduction into tissues: epicondylitis, tendinous synovitis, bursitis, frozen shoulder, keloids, ischialgias, Dupuytren’s contracture, rheumatic and similar to them joint diseases and that of various tissues.
- Action
Prednisolone takes evidenced anti-inflammatory and antiallergic action, it possesses anti-shock and immuno-suppressing activity. The drug affects various types of metabolism: it increases the level of glucose in blood and favors the redistribution of fat tissue. Prednisolone affects inflammatory process in connective tissue and reduces the possibility of the formation of scar tissue.
While local administration Prednisolone takes anti-inflammatory and anti-allergic effect.
- Posology and Administration
For oral administration. In replacement therapy - adults are administered in the starting dose 20-30 mg a day, supporting dose is 5-10 mg a day. If necessary the starting dose may be 15-100 mg a day, the supporting one may be 5-15 mg daily. A daily dose of the drug should be decreased step by step. For children the starting dose is 1-2 mg/kg of the body mass daily in 4-6 intakes, a supporting one is 0.3-0.6 mg/kg daily.
For injections. In intramuscular introduction a dose, repetition factor and term of use should be determined individually. In intra-articular introduction in big joints there is used a dose of 25-50 mg, for medium size joints a dose should be 10-25 mg, for small joints a dose should be 5-10 mg. For infiltration introduction into tissues, depending on severity of the disease and the size of the damage area, the doses are used from 5 to 50 mg.
For local use. In ophthalmology: the drug in the form of eye suspended matter will be instilled 1-2 drops each into a conjunctival sac 3 times daily; the treatment course should be not more than 14 days. In dermatology: ointment should be rubbed into afflicted parts of skin 1-3 times a day.
- Counterindications
Ulcer stomach and duodenal disease, osteoporosis, Cushing’s basophilism, tendency to thromboembolia, renal failure, severe arterial hypertension, constitutional mycoses, virus infections, a period of vaccination, active form of tuberculosis, glaucoma, mental illnesses. Hypersensitivity to the drug.
For washing of damage centers of cutaneous coverings and tissues: in chicken pox, specific infections, mycoses, in vaccination local reaction.
In ophthalmology: viral and bacterial diseases of eyes, primary glaucoma, cornea disease with epithelium damage. In dermatology – bacterial, viral skin damages, pinta, tuberculosis, syphilis, skin tumors.
- Should Be Taken with Precautions, if…
Prednisolone therapy should be administered by a doctor and should be done under his or her control. The drug is not indicated for intravenous introduction. When there is a history of psychoses Prednisolone in high doses should be administered under a doctor’s order. In sugar diabetes the drug should be administered when there are absolute indications or for the prevention of a supposed insulin tolerance of organism. In latent tuberculosis forms Prednisolone may be applied only in combination with anti-tuberculosis medications.
After the cessation of treatment there may emerge a withdrawal syndrome, adrenal insufficiency, likewise aggravation of the disease, concerning which Prednisolone has been administered.
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Interface with Other Medications
Full responsibility is needed on the application of Prednisolone, moreover administration and cure should necessarily be with direct involvement and under control of a doctor. It is necessary to receive from him or her precise information about the drugs which are strongly not recommended to take during Prednisolone therapy.
- Overdosing
Overdosing risk is enhanced when there is a long-lasting Prednisolone therapy, especially in big doses.
Symptoms: elevation of arterial tension, peripheral edemas, enhancement of side effects of the drug.
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Side Effects
Frequency of development and evidence of side effects depend on the mode, time duration of the use of a dose.
Liquid retention in the body, compromised kidneys functions, growth inhibition in children, menstrual cycle disorders; elevation of arterial tension, development (in predisposed patients) or enhancement of manifestation of chronic heart failure, muscle weakness, loss of muscle mass, pathologic breaks of long tubular bones, stomach ulcer, indigestion, nausea, vomit, rise of appetite, pimples, delayed wound healing, skin thinning, elevated perspiration, allergic reactions, mental disorders, headache, impairment of vision or double vision, sleep disorder, dizziness; sudden loss of vision, increase of intraocular pressure with a potential damage of visual nerve, general weakness, symptoms masking infection diseases, fainting fits, withdrawal syndrome.
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Pregnancy and Lactation
Women of child-bearing age should be warned about potential risk for the fetus. In pregnancy (especially in the I-st trimester) the drug should be used on salvage indications only. If possible Prednisolone administration should be avoided.
Nursing mothers should either stop breastfeeding or withdraw using Prednisolone; especially in high doses Prednisolone excretes into breast milk and may provoke adverse effects in newborns.
- Driving
Prednisolone’s influence on human alertness is rather high, therefore car driving is not recommended.
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