Generic Avandamet

1. Denomination

Glucophage

2. Active Substance

Metformin

3. Indications for Use.

Sugar diabetes of type 2 in adults (in the cases when diet therapy is inefficient), especially in obesity cases. Sugar diabetes of type 1 as an addition to insulin therapy.

4. Action

Metformin decreases absorption of carbohydrates, deflates the concentration of glucose, increases the tolerance to glucose, decreases the body mass.

5. Posology and Administration

A dose is to be picked individually. Metformin should be taken orally, immediately after meal; non-insulin patients should take 1 g (2 tablets) 2 times a day in the first 3 days or 500 mg each 3 times a day, and in future - from the 4-th to the 14-th day 1 g each 3 times a day; after 15 days a dosage may be reduced with respect to glucose content in blood and urine. A supporting daily dose is 1-2 g. Retard tablets (850 mg) are to be taken 1 each in the morning and in the evening. The maximal daily dose is 3 g.
Simultaneous use of insulin with the drug demands great care and should be done at hospital.

6. Counterindications

Childhood (efficiency and safety of the use in children is not determined) and elderly age (over 65 years) age. Hypersensitivity, kidneys disease – evidenced compromised liver function, heart and respiratory failure, acute phase of myocardial infarction, infectious diseases, major surgeries and traumas, chronic alcoholism, pregnancy, breastfeeding.

7. Should Be Taken with Precautions, if…

During the treatment kidneys function and blood composition control is needed. During Metformin therapy hard physical work is not recommended.
Combined use of the drug with insulin is recommended to carry out at hospital.

8. Interface with Other Medications

Interface with other medications may give adverse side effects. In this respect it is recommended to inform your doctor which medications you take or have taken at the last period of time. On the matter of drug combination it is necessary to take advice of your attending doctor.

9. Overdosing

Metabolic disorder.

10. Side Effects

Nausea, vomiting, “metallic” off-flavor, loss of appetite, pain in the stomach, weakness, pain in muscles, respiratory disorders, drowsiness, deflation of arterial tension, skin rash. In cases of emergence of side effects the dose should be reduced or temporary withdrawn

11. Pregnancy and Lactation

Metformin should be administered in the period of pregnancy. During the treatment breastfeeding should be stopped.

12. Driving

In the period of Metformin therapy it is necessary to refrain from potentially hazardous activities which require alertness and rapidity of psychomotor actions.

DIABETES AND EXERCISE: TERTIARY PREVENTION OF TYPE 2 DIABETES MELLITUS
A recent review from the Joslin Diabetes Center at Harvard University concluded that the individual with type 2 diabetes can benefit from appropriate levels of physical activity and dietary intervention, and that the positive effects of physical activity include:
- Increased energy expenditure
- Decreased body fat (particularly if combined with dietary restriction)
- Increased insulin sensitivity
- Improved long-term glycemic control
- Improved lipid profiles
- Lower blood pressure
- Increased cardiovascular fitness.
Another recent review concluded that since most patients with diabetes die from complications of atherosclerosis, they should receive intensive preventive interventions proven to reduce their cardiovascular risk. Note that physicians should be careful in prescribing physical activity for patients with clinical type 2 diabetes. Patients may find it difficult to exercise and they are at increased risk for injury, exacerbation of underlying diseases, or metabolic complications.
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DIABETES

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