Generic Asendin (Amoxapine 50/100mg)
AMOXAPINE
Tablets: 25, 50, 100, and 150 mg (Rx) Various, Asendin (Lederle)
Indications
Relief of symptoms of depression.
Agents with significant sedative action may be useful in depression associated with anxiety and sleep disturbances.
Relief of depressive symptoms in patients with neurotic or reactive depressive disorders and endogenous and psychotic depression; depression accompanied by anxiety or agitation.
Administration and Dosage
Amoxapine is not recommended for patients
Usual effective dose range is 200 to 300 mg/day. If no response is seen at 300 mg, increase dosage, depending upon tolerance, to 400 mg/day. Hospitalized patients refractory to antidepressant therapy and who have no history of convulsive seizures may have dosage cautiously increased up to 600 mg/day in divided doses.
Adults - Initially, 50 mg 2 or 3 times/day. Depending upon tolerance, increase dosage to 100 mg 2 or 3 times/day by the end of the first week. Increase above 300 mg/ day only if 300 mg/day has been ineffective for at least 2 weeks. Once an effective dosage is established, the drug may be given in a single bedtime dose (not to exceed 300 mg). If the total daily dosage exceeds 300 mg, give in divided doses.
Elderly patients - Initially, 25 mg 2 or 3 times a day. If tolerated, dosage may be increased by the end of the first week to 50 mg 2 or 3 times a day. Although 100 to 150 mg/day may be adequate for many elderly patients, some may require higher dosage; carefully increase up to 300 mg/day. Once an effective dosage is established, give amoxapine in a single bedtime dose, not to exceed 300 mg.
ANTI-DEPRESSANT
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