Generic Afeditab Er

1. Denomination

Adalat, Procardia

1. Active Substance

Nifedipine

1. Indications for Use.

- Prevention of stenocardia attacks (including Prinzmetal’s angina);
- Arterial hypertension;
- Hypertrophic cardiomyopathy;
- Raynaud’s disease.

1. Action

Nifedipine has got antianginal and antihypertensive potency.
Under the drug’s influence coronary vessels are dilated, coronary circulation is improved, oxygen consumption in myocardium is reduced. The drug also induces increase of a lumen of blood vessels, reduces general peripheral resistance of vessels and reduces arterial tension. Nifedipine does not exert an inhibitory effect on cardiac conduction system.

1. Posology and Administration

The drug should be used strictly on a doctor’s order to avoid aggravations!
Posology and administration is to be determined individually in every case.
The starting dose is 1 tablet (10 mg) 2 times a day. If needed a dose may be increased up 2 tablets (20 mg) 4 times a day. The maximal daily dose is 80 mg.

1. Counterindications

Arterial hypotension (systolic pressure is less than 90 mm of mercury column), tachycardia, collapse, insult to the brain, cardiogenic shock, decompensation heart failure, bad aortic stenosis, acute period of myocardial infarction (during the first 4 weeks), hypersensitivity to Nifedipine; childhood.

1. Should Be Taken with Precautions, if…

The drug should be administered with caution to patients suffering from evidenced heart failure, severe disorders of brain circulation, diabetes, and malign hypertension. With caution it should be administered to patients with compromised function of liver and kidney. When there is acute treatment cessation and stenocardia - it may emerge progression of “withdrawal” syndrome, in aassociation with it the treatment should be ceased gradually. During Nifedipine therapy one must refrain from alcohol consumption.

1. Interface with Other Medications

On the matter of parallel administration of another drug during Nifedipine therapy see your attending doctor.

1. Overdosing

Symptoms: excessive drop of arterial tension; if a big quantity of tablets have been taken there may be tachycardia, bradycardia, arrhythmia, nausea, vomiting, weakness, skin redness, dizziness, drowsiness, retardation, disorder of color sensation, convulsions, loss of consciousness.

1. Side Effects

In the beginning of the treatment there may be headaches, dizziness, apathy, drowsiness, drop of arterial tension, heartbeat, pains in the stomach, indigestion, swelling of gums (after a longer use), allergic rash, pricky and numbness sensation in the limbs, edema of lower limbs, retrosternal pains, enhancement of stenocardia attacks, pains in muscles, disturbance of vision, disturbance of heart rhythm, breast pains. Very seldom there are noticed progression of arthritis (mainly of knee joint), elevation of appetite and/or of the body weight.

1. Pregnancy and Lactation

The drug should not be used in pregnancy and breast-feeding.

1. Driving

The drug should be administered with caution to drivers of vehicles and operators of machinery, as while Nifedipine therapy there may be retardation of psychic and motion reactions and disorders of attention concentration.

HEART DISORDERS: CONGENITAL OBSTRUCTIONS TO THE FREE-FLOW OF BLOOD
There are three causes of congenital obstructions; these can often be serious, and must be corrected urgently. They are:
1. Stenosed valves due to fusion of the cusps, especially in the pulmonary valve but also in the aortic and tricuspid valves. Congenital stenosis of the mitral valve is rare.
2. Underdevelopment of an area due to decreased flow of blood to the heart. This can be a major problem in the Tetralogy of Fallot.
3. Overgrowth of muscle tissue in the heart.
The correction of these conditions is often a complex procedure, involving the opening of the valves (which can be very tricky with the aortic valve, as any backflow can be fatal); enlarging underdeveloped areas with grafts from the patient's own tissues or with artificial materials such as Teflon, or even bypassing the area if it is very underdeveloped; and, in the event of an overgrowth, cutting away obstructing muscle bands. Techniques are improving all the time.
*18/353/5*
CARDIO & BLOOD

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