Generic Actoplus Met

1. Denomination

Glucophage

2. Active Substance

Metformin

3. Indications for Use.

Sugar diabetes of type 2 in adults (in the cases when diet therapy is inefficient), especially in obesity cases. Sugar diabetes of type 1 as an addition to insulin therapy.

4. Action

Metformin decreases absorption of carbohydrates, deflates the concentration of glucose, increases the tolerance to glucose, decreases the body mass.

5. Posology and Administration

A dose is to be picked individually. Metformin should be taken orally, immediately after meal; non-insulin patients should take 1 g (2 tablets) 2 times a day in the first 3 days or 500 mg each 3 times a day, and in future - from the 4-th to the 14-th day 1 g each 3 times a day; after 15 days a dosage may be reduced with respect to glucose content in blood and urine. A supporting daily dose is 1-2 g. Retard tablets (850 mg) are to be taken 1 each in the morning and in the evening. The maximal daily dose is 3 g.
Simultaneous use of insulin with the drug demands great care and should be done at hospital.

6. Counterindications

Childhood (efficiency and safety of the use in children is not determined) and elderly age (over 65 years) age. Hypersensitivity, kidneys disease – evidenced compromised liver function, heart and respiratory failure, acute phase of myocardial infarction, infectious diseases, major surgeries and traumas, chronic alcoholism, pregnancy, breastfeeding.

7. Should Be Taken with Precautions, if…

During the treatment kidneys function and blood composition control is needed. During Metformin therapy hard physical work is not recommended.
Combined use of the drug with insulin is recommended to carry out at hospital.

8. Interface with Other Medications

Interface with other medications may give adverse side effects. In this respect it is recommended to inform your doctor which medications you take or have taken at the last period of time. On the matter of drug combination it is necessary to take advice of your attending doctor.

9. Overdosing

Metabolic disorder.

10. Side Effects

Nausea, vomiting, “metallic” off-flavor, loss of appetite, pain in the stomach, weakness, pain in muscles, respiratory disorders, drowsiness, deflation of arterial tension, skin rash. In cases of emergence of side effects the dose should be reduced or temporary withdrawn

11. Pregnancy and Lactation

Metformin should be administered in the period of pregnancy. During the treatment breastfeeding should be stopped.

12. Driving

In the period of Metformin therapy it is necessary to refrain from potentially hazardous activities which require alertness and rapidity of psychomotor actions.

PHYSICAL ACTIVITY AND METABOLIC DISEASES: PRIMARY PREVENTION OF TYPE 2 DIABETES MELLITUS
The CDC (Centers for Disease Control and Prevention) asserts that type 2 diabetes is largely preventable by changes in lifestyle. The director of the CDC wrote: "Restoring physical activity to our daily routines is crucial to the future reduction of diabetes and obesity in the U.S. population." The adverse effects of eliminating physical activity and increasing sedentary time (such as TV viewing) are dramatic. Certain and Kahn's study of TV viewing in childhood suggests that:
- it initiates biological and behavioral events that facilitate the long pre-clinical period before overt clinical symptoms of type 2 diabetes appear
- it substitutes sedentary time for physically active time.
Hu et al examined the relationship between TV viewing and diabetes in adults: 37,918 health professionals (physicians, dentists, optometrists, pharmacists, podiatrists, osteopaths, and veterinarians) aged 40-75 yrs reported their TV viewing for 10 years, and the data was normalized to 1.0 for the lowest level of weekly physical activity (0-5.9 MET hr/week). The relative risk of type 2 diabetes was dramatically reduced by half in those with > 40.9 MET hr/wk, compared to those engaging in the least physical activity and most TV viewing time. Every additional18 MET hr/wk of physical activity was associated with a 19% reduction in riskoftype2 diabetes. Every 2-hour increment spent watching TV was associated with an additional 50% increase in the risk of diabetes. Those viewing TV the most were at more than twice the risk.
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DIABETES

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